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抗生素尾酒对早期肉肠道微生物群落,屏障功能和免疫功能的影响

Waseem Abbas¹, Ruichen Bi¹, Muhammad Dilshad Hussain^2,3

¹State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100093, China.

Antibiotics (Basel, Switzerland)

|May 24, 2024

概括

在 brojlers 中使用抗生素尾酒会破坏肠道微生物群,延迟肠道发育,并损害肠道屏障功能. 这项研究为进一步的肠道健康研究建立了一个低细菌模型.

科学领域:

动物科学动物科学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

在家禽养殖中使用抗生素可以显著改变肠道微生物群.
了解抗生素对 brojler肠道健康的影响对于动物福利和食品安全至关重要.

研究的目的:

为了研究广泛的抗生素尾酒对肠道微生物组成,屏障结构和早期肉的免疫功能的影响.
为未来的肠道微生物群研究建立可靠的低细菌模型.

主要方法:

一天大的肉被用抗生素尾酒 (ABX) 或对照治疗了7天和14天.
使用16S rRNA测序来分析肠道微生物组成.
评估了肠道形态,血清免疫标记物,基因表达和小肠短链脂肪酸.

主要成果:

ABX治疗减少了有益的细菌 (Firmicutes, Lactobacillus) 和增加了潜在的病原体 (Enterococcus, Bacteroidetes, 蛋白质细菌).
长时间暴露于ABX (14天) 导致肠道重量/长度,小高度,密室深度下降,免疫反应发生变化 (增加LPS,TNF-α,IFN-γ,IgG).
ABX治疗降低了肠道屏障基因 (occludin,ZO-1,mucin 2) 的调节,减少了杯状细胞数量和有益的短链脂肪酸.

结论:

长时间在 brojlers 中使用抗生素会诱导肠道失调,损害肠道发育和屏障功能,并扰乱免疫反应.
这项研究提供了一种有价值的低细菌模型,用于通过便微生物移植研究肠道微生物群功能.

关键词:

一个抗生素尾酒.早期的肉早期的肉我们的肠道微生物群.免疫力是一种免疫力.肠道屏障功能肠道屏障功能

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