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系统性审查和元分析没有为治疗无症状细菌尿症在移植后的第一年提供指导
José Medina-Polo1, Eva Falkensammer2, Béla Köves3
1Department of Urology, Hospital Universitario 12 de Octubre imas12, 28040 Madrid, Spain.
Antibiotics (Basel, Switzerland)
|May 24, 2024
概括
查和治疗无症状细菌性尿病 (ASB) 在移植 (KT) 接受者似乎没有降低尿路感染 (UTI) 或移植损失的风险. 目前的证据不支持在移植后进行常规的ASB管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植 移植 移植 移植
- 传染性疾病 传染性疾病
背景情况:
- 尿路感染 (UTI) 是接受移植 (KT) 患者的常见并发症.
- 无症状细菌性尿症 (ASB) 是这些患者尿路感染和移植排斥的潜在危险因素.
研究的目的:
- 评估脏移植后第一年ASB查和治疗的证据.
- 确定ASB管理是否影响尿路感染,败血症,功能衰竭和死亡率等结果.
主要方法:
- 在 MEDLINE,Cochrane Library CENTRAL 和 Embase 上进行了系统的文献搜索.
- 研究包括成人KT接受者,重点关注ASB查,诊断和治疗与没有抗生素治疗.
- PICO标准指导了搜索,结果包括尿路感染,败血症,移植损失和死亡率.
主要成果:
- 没有证据表明在未经治疗的ASB患者中,下部尿路感染,急性骨髓炎,移植损失或死亡率更高.
- 对比性非随机和观察性研究的分析未能为临床建议提供补充证据.
- 缺乏证据可能源于在研究患者分层中未考虑的混风险因素.
结论:
- 目前的证据不支持在移植患者中进行ASB的常规查或抗生素治疗.
- 需要进一步的研究来澄清ASB及其管理在KT结果中的作用,考虑到混因素.
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