在潜伏感染期间,Mycobacterium tuberculosis不太可能获得病原性突变,而不是在活跃疾病期间
Asami Osugi1, Aki Tamaru2, Takashi Yoshiyama3,4
1Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Tokyo, Japan.
Microbiology spectrum
|May 24, 2024
概括
潜伏性结核病 (TB) 感染 (LTBI) 涉及 Mycobacterium tuberculosis (Mtb) 在低选择性压力下积累较少的突变. 这表明LTBI是新结核病的来源,而不是在宿主基因组显著进化的时期.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 潜伏性结核病感染 (LTBI) 是一种Mycobacterium结核病 (Mtb) 无症状持续存在的状态.
- 即使在几十年后,LTBI也存在重新激活到活跃疾病的风险.
- 了解LTBI期间的Mtb基因组动态对于结核病控制策略至关重要.
研究的目的:
- 为了描述MTb在LTBI期间获得的突变.
- 为了比较LTBI中Mtb的基因组演变与活跃结核病的基因组演变.
- 评估在感染的不同阶段对Mtb的选择性压力.
主要方法:
- 分析来自日本患者对的mtb基因组,对LTBI的怀疑有所不同.
- 与慢性活跃结核病感染和公共数据的纵向样本进行比较.
- 单核酸多态 (SNP) 的识别和分析,以推断突变速率和选择.
主要成果:
- 在LTBI患者中,mtb群体在遗传上更为均,积累的SNP比在活跃疾病中慢.
- 在LTBI中非同义SNP的比例较低表明选择压力较弱.
- 不同的突变谱表明LTBI与活跃疾病的突变过程不同.
结论:
- 在LTBI期间,mtb积累了突变,但是在低选择性压力下.
- 在LTBI期间,获得赋予抗生素耐药性或增加毒性突变的可能性较小.
- LTBI可能会成为新结核病例的储存库,而不是Mtb在宿主进化的重要时期.
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