乳腺癌的临界风险评估,诊断和生存分析
Shamiha Binta Manir1, Priya Deshpande1
1Department of EECE, Marquette University, Milwaukee, WI 53233, USA.
Diagnostics (Basel, Switzerland)
|May 24, 2024
概括
这项研究使用机器学习来预测乳腺癌风险,诊断它,并使用三个数据集分析生存率. 机器学习模型,特别是随机森林和K-Nearest Neighbor,在改善乳腺癌检测和理解方面表现有前途.
科学领域:
- 瘤学和生物信息学
- 计算生物学和数据科学数据科学
背景情况:
- 乳腺癌是女性的主要癌症,需要改进风险评估和早期检测策略.
- 个性化医疗方法对于有效的乳腺癌管理至关重要,承认疾病异质性.
研究的目的:
- 使用乳腺癌监测联盟 (BCSC) 风险因素数据集开发乳腺癌风险预测模型.
- 使用威斯康星州乳腺癌诊断数据集来诊断乳腺癌.
- 分析乳腺癌存活率与监测,流行病学和最终结果 (SEER) 乳腺癌数据集.
主要方法:
- 应用各种预处理技术,包括主要组件分析 (PCA) 和重新采样策略 (例如,Tomek Link).
- 评估了多个机器学习分类器,例如随机森林和K-Nearest Neighbor.
- 在SEER数据集上使用监督和无监督学习进行生存分析.
主要成果:
- 随机森林在BCSC数据集上获得了87.53%的准确率;Tomek Link重新抽样提高了测试准确率至87.47%.
- K-Nearest Neighbor在威斯康星州原始数据集上达到94.71%的准确性,在PCA转换的诊断数据集上达到95.29%的准确性.
- 生存分析提供了对影响乳腺癌患者结果的因素的见解.
结论:
- 机器学习模型,特别是随机森林和K-Nearest Neighbor,在乳腺癌风险预测,诊断和生存分析方面显示出重大潜力.
- 数据驱动的洞察力和先进的分析技术对于推进个性化乳腺癌医学至关重要.
- 该研究强调了个性化方法在乳腺癌管理的重要性,通过考虑表型变异.
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