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皮炎和超重幼儿的肠道菌群:芬兰的一项前性队列研究

Petri Vänni¹, Jenni Turunen^1,2, Ville K Äijälä³

¹Research Unit of Clinical Medicine, University of Oulu, 8000 Oulu, Finland.

Journal of fungi (Basel, Switzerland)

|May 24, 2024

概括

儿童的肠道菌群或真菌群体表现出与亚托皮炎 (AD) 和超重相关的明显模式. 像Saccharomyces这样的特定真菌可能在这些条件的发展中发挥作用.

科学领域:

微生物学微生物学
儿科健康儿科健康
免疫学免疫学免疫学

背景情况:

肠道细菌变化与成人非传染性疾病有关,但肠道菌群的作用,特别是在儿童中,仍未得到充分研究.
很少有研究探讨了小儿群体的肠道菌群和非传染性疾病之间的关联.

研究的目的:

为了研究婴儿和儿童的肠道菌群组成.
确定肠道真菌生物组模式与儿童亚托皮炎 (AD) 和超重的发展之间的关系.

主要方法:

分析了194个便样本,这些样本是在出生时,出生后6个月和出生后18个月收集的.
利用机器学习 (ML) 来识别与AD和超重诊断相关的关键真菌种群.

主要成果:

观察到明显的真菌生物组模式,在出生时流行Truncatella,在6个月和18个月的超重婴儿中占主导地位的Saccharomyces,在6个月的非超重婴儿中占主导地位的Malassezia.
在患有阿尔茨海默氏症和超重儿童中, *Saccharomyces* 一致丰富.
ML分析表明肠道菌群 (包括未识别的真菌,Alternaria,Rhodotorula,Saccharomyces,Thelebolus和Dothideomycetes) 和AD/超重发育之间的关联.

结论:

儿童的肠道菌群组成表现出明显的模式,可能与亚托皮炎和超重的发展有关.
特定的真菌种群,如Saccharomyces,显示出作为这些儿科疾病的生物标志物或贡献者的潜力.

关键词:

亚托邦性皮肤炎的发生.亚托皮亚托皮亚亚托皮亚是什么意思孩子们的孩子们的孩子们的孩子们菌是一种真菌.婴儿婴儿婴儿婴儿婴儿机器学习是机器学习.微生物组是一个微生物组.这就是我的mycobiome.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖这是一个前性的前性.

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