流体摄入对血体积急性变化的影响:一个随机控制的交叉试验试验
Janis Schierbauer1, Sabrina Sanfilippo1, Auguste Grothoff1
1Division of Exercise Physiology and Metabolism, Bayreuth Centre of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Metabolites
|May 24, 2024
概括
摄入液体对健康个体的血体积 (PV) 有显著影响. 同位素化和林格溶液急剧增加PV,证明了水合和液体度对血液体积的重要性.
科学领域:
- 身体生理学 身体生理学
- 流体平衡 流体平衡 流体平衡
- 血液动力学 血液动力学
背景情况:
- 血体积 (PV) 在健康个体中表现出显著的每日波动.
- 水会影响PV,但透性多样化的液体的影响仍然不清楚.
研究的目的:
- 为了研究口服的同位素化,林格和葡萄糖溶液对血体积的急性影响.
- 为了比较流体诱导的PV变化与没有流体摄入的控制条件.
主要方法:
- 随机对照交叉试验涉及18名健康参与者.
- 单个量同位素化 (ISO),林格 (RIN) 或葡萄糖 (GLU) 溶液的口服.
- 测量血红蛋白质量 (Hbmass) 并根据毛细血管血红蛋白度 ([Hb]) 和血红素 (Hct) 在120分钟内计算PV变化.
主要成果:
- 葡萄糖 (GLU) 和对照 (CON) 组没有显著的基线PV变化.
- 与基线和对照相比,同位素化 (ISO) 从70到110分钟显著增加了PV.
- 与基线相比,Ringer (RIN) 的PV从70分钟增加到90分钟,并在110-120分钟显著增加.
结论:
- 口服含有较高透活性颗粒含量的液体会诱导急性血液稀释.
- 这种血液稀释的特点是血红蛋白度和血液度的下降.
- 水状态和液体度是血体积及其成分的关键决定因素.
相关概念视频
Hormonal Regulation of Blood Pressure
2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K
Regulation of Water Intake
499
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
499
Disorder of Water Balance
365
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
365
Fluid Movement Between Compartments
509
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
509
Body Water Content and Fluid Compartments
675
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
675
Heart Failure Drugs: Diuretics
363
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
363


