通过连续超临界CO2辅助过程产生PEGylatedVancomycin-LoadedNiosomes
Lucia Baldino1, Domenico Riccardi1, Ernesto Reverchon1
1Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
Nanomaterials (Basel, Switzerland)
|May 24, 2024
概括
基化尼奥索姆有效控制了万科米辛的释放. 这项研究使用超临界CO2过程产生纳米囊泡,证明PEGylated niosomes显著延长药物释放.
科学领域:
- * 制药科学 制药科学
- * 纳米技术的使用
- * 材料科学 材料科学
背景情况:
- * 体具有成本效益,生物相容性和低毒性.
- * 范科米辛是一种关键的抗生素,需要控制的输送.
- * 超临界二氧化碳处理是一种新兴的纳米粒子制造技术.
研究的目的:
- * 用超临界的CO2来产生体.
- * 将万科米辛封装在阴阳体内.
- * 为了比较PEGylated和非PEGylated阴酶体的药物释放特征.
主要方法:
- * 超临界的CO2辅助过程在100bar和40°C.
- *使用胆固醇和Span 80/Tween 80的尼奥索姆配方.
- * 作为模型活性化合物的万科米辛封装.
- * 囊泡大小和药物封装效率的表征.
主要成果:
- *成功生成了纳米级囊泡 (214 ± 59 nm和254 ± 73 nm).
- * 实现了高范科米辛封装效率 (95%和98%).
- * 与药物粉末相比,PEGylated niosomes 延长了万科米辛的释放时间达到了20倍.
结论:
- * 超临界的二氧化碳是有效的生产体.
- * PEGylation显著增强了药物释放控制.
- * PEGylated niosomes 是一种有前途的策略,可以控制菌素的输送.
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