史蒂维oside (Stevia rebaudiana) 对Entamoeba histolytica (类植物) 的影响
Karla Jocelyn Ortega-Carballo1, Karla Montserrat Gil-Becerril1, Karla Berenice Acosta-Virgen1
1Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, Mexico City 07360, Mexico.
Pathogens (Basel, Switzerland)
|May 24, 2024
概括
石酸 (STV) 对E. histolytica表现出氨杀性活性,为治疗氨病提供了一种潜在的替代甲尼达的替代品. 这种植物化学化合物对寄生虫生存能力和形态学产生了显著影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 寄生虫学的寄生虫学
- 自然产品 化学 化学
背景情况:
- 人类的蜂蜜病仍然是一个重大的全球健康问题.
- 主要治疗方法美特罗尼达会引起不良反应,需要使用替代疗法.
- 植物化学物质正在被探索,因为它们的抗性质.
研究的目的:
- 为了评估来自Stevia rebaudiana的化 (STV) 的氨杀菌活性.
- 为了研究STV对E. histolytica trophozoites的影响.
主要方法:
- 在E. histolytica trophozoites上测试各种STV度.
- 确定细胞活力的抑制度50% (IC50).
- 分析形态和超结构变化,囊蛋白酶表达和蛋白质分解活性.
- 用STV治疗的受感染的仓鼠肝脏的组织学检查.
主要成果:
- 在24小时暴露后,STV显示IC50为9.53mM.
- 热带动物表现出改变的形态,减少的运动性/粘附性结构,以及细胞膜和细胞质的变化.
- 观察到囊蛋白酶表达和蛋白质分解活性下降.
- 仓鼠肝脏组织学揭示了对STV治疗的反应中的颗粒状反应.
结论:
- 石酸对E. histolytica.表现出显著的氨杀效应.
- STV会诱导 trofhozoites 的形态和功能损伤.
- 这些研究结果表明,STV是氨核病的有希望的治疗候选者.
相关概念视频
00:46Trophic Efficiency
Trophic level transfer efficiency (TLTE) is a measure of the total energy transfer from one trophic level to the next. Due to extensive energy loss as metabolic heat, an average of only 10% of the original energy obtained is passed on to the next level. This pattern of energy loss severely limits the possible number of trophic levels in a food chain.
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:21Antiprotozoal Agents
Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...