益生菌补充剂对口腔微生物群的影响-一篇叙述性评论
Christine Lundtorp-Olsen1, Merete Markvart1, Svante Twetman1
1Department of Odontology, Section for Clinical Oral Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Pathogens (Basel, Switzerland)
|May 24, 2024
概括
益生菌补充剂对口腔健康状况 (如牙炎和) 显示出混合的结果. 由于研究设计的多样性和临床试验中先进分子方法的有限使用,它们对口腔微生物群的确切影响尚不清楚.
科学领域:
- 口腔微生物学 口腔微生物学
- 益生菌研究的研究.
- 临床试验方法论 临床试验方法论
背景情况:
- 系统性审查表明益生菌有益于口腔健康 (牙炎,牙损伤,牙周炎).
- 益生菌机制涉及与口腔微生物群和宿主的相互作用.
- 了解这些机制需要详细的微生物学分析.
研究的目的:
- 从随机临床试验 (RCT) 中审查口服益生菌的微生物效应.
- 评估分子方法在口服益生菌RCT中的应用.
- 识别当前研究中的差距,以实现未来的改进.
主要方法:
- 关于口服益生菌的随机临床试验 (RCT) 的叙述性综述.
- 专注于报告微生物终点的研究.
- 在这些RCT中使用的分子技术的评估.
主要成果:
- 关于益生菌对口腔微生物群的影响的RCT结果是矛盾的.
- 研究设计,样本大小和益生菌管理的显著异质性阻碍了比较.
- 在现有的RCT中有限地使用先进的分子技术 (例如16S测序,元基因组学).
结论:
- 口服益生菌补充剂的微生物影响尚不清楚.
- 大多数RCT缺乏微生物学评估,阻碍了机制的阐明.
- 需要对口服益生菌RCT中的微生物终点进行标准化报告,以提高研究质量.
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