无育史和结肠直肠癌的风险
Leslie V Farland1,2,3, Kimberly E Lind4, Denise J Roe1,3
1Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.
概括
在绝经后的妇女中,不孕不育与结直肠癌风险无关. 这项研究没有发现患有不孕症的女性患结直肠癌或相关死亡率的风险增加.
科学领域:
- 生殖健康 生殖健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于不孕不育和结直肠癌风险之间的联系的研究有限.
- 了解潜在的联系对于全面的妇女健康至关重要.
- 调查结直肠癌的危险因素是一个持续的公共卫生优先事项.
研究的目的:
- 调查自我报告的不孕不育与绝经后妇女患结直肠癌的风险之间的关联.
- 为了确定不孕是否会影响入侵性结直肠癌的风险或结直肠癌死亡率.
主要方法:
- 利用了来自妇女健康倡议队列的数据,重点关注绝经后妇女.
- 定义不孕症为12个月试图怀孕但没有成功.
- 采用Cox的比例危险模型来分析不孕症和结直肠癌结局之间的关系.
主要成果:
- 没有发现不孕不育与绝经后结直肠癌的风险之间有统计学意义的关联 (RR,0.97;95% CI,0.87-1.08).
- 不孕不育与侵袭性结直肠癌的风险增加没有相关性 (RR,0.99;95% CI,0.88-1.10).
- 在不孕症和结直肠癌死亡率之间没有观察到任何关联 (RR,0.89;95% CI,0.71-1.12).
结论:
- 在绝经后的女性中,不孕不育与结直肠癌的风险增加无关.
- 结直肠癌的风险并没有根据特定的不孕症诊断有所不同.
- 研究结果表明,不孕不育不太可能是这种人群中结直肠癌的危险因素.
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