向与瘤相关的巨细胞,以逆转抗瘤药物耐药性
Sheng Li1, Jiyao Sheng2, Dan Zhang2
1The Second Hospital of Jilin University, Changchun, China.
Aging
|May 24, 2024
概括
与瘤相关的巨细胞 (TAMs) 通过促进免疫抑制和血管生成来驱动对抗瘤药物的耐药性. 向TAM可以重新编程瘤微环境,提高治疗效率.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗瘤药物由于适应性耐药性而表现出有限的临床疗效.
- 瘤微环境 (TME),特别是与瘤相关的巨细胞 (TAMs),显著影响治疗结果.
- TAMs可以采用免疫抑制和亲血管生成的表型,从而导致耐药性和不良预后.
研究的目的:
- 审查巨细胞响应在抗瘤治疗中的作用.
- 探索针对TAM的免疫调节作为治疗策略.
- 提出涉及TAM调制和传统抗瘤药物的组合策略.
主要方法:
- 对TAM和抗瘤治疗的临床前和临床研究的文献综述.
- 分析TAMs调解药物耐药性的机制.
- 对TAM再极化和功能调制的策略的评估.
主要成果:
- 通过外部抑制剂,TAMs可以被重新编程为类似M1的表型,从而提高治疗疗效.
- 巨细胞的药理调节可以恢复免疫刺激特征,重塑TME.
- 向TAM提供了一种有希望的方法来克服耐药性和限制瘤生长.
结论:
- 调节TAM是一种可行的策略,可以增强传统的抗瘤疗法.
- 重编程TAM可以逆转TME内的免疫抑制和益血管性活动.
- 针对TAM的免疫调节与常规药物的联合治疗有可能改善癌症治疗.
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