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乳腺癌组织中的BECN1mRNA表达;与瘤等级有显著的相关性

Sarah Ahmed Aglan¹, Ahmed Mostafa Awad¹, Yasmine Nagy Elwany²

¹Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Molecular genetics and genomics : MGG

|May 24, 2024

概括

乳腺癌 (BC) 中的贝克林1 (BECN1) 表达与瘤分化较差相关,但与无病生存率无关. 与光线BC相比,三阴BC显示出不太有利的预后.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
分子病理学分子病理学

背景情况:

乳腺癌 (BC) 异质性涉及多种途径,包括自,对癌症进展和耐药性至关重要.
自蛋白贝克林1 (BECN1) 的哈普洛缺乏症与癌症的发病和进展有关.
研究BECN1的作用对于理解BC发育和确定治疗点至关重要.

研究的目的:

在埃及女性乳腺癌患者队列中研究贝克林1 (BECN1) 表达.
通过评估其与无病生存率 (DFS) 和临床病理特征的关联来评估BECN1的预后作用.
探索BECN1表达和乳腺癌攻击性之间的关系.

主要方法:

在20个冷的女性BC组织样本和17个相邻的正常组织中检查了BECN1表达水平.
评估了BECN1表达与瘤阶段,结节转移,瘤大小和瘤等级的关联.
分析了BECN1表达和2年无病生存期 (DFS) 之间的相关性,包括三重阴性 (TNBC) 和光线BC亚型之间的比较.

主要成果:

瘤组织中的BECN1表达低于正常组织,但这种差异在统计学上并不显著 (p=0.463).
BECN1表达与病期,结节转移或瘤大小 (p>0.05) 没有显著的关联.
在瘤等级和BECN1mRNA表达之间发现了显著的负相关性 (p=0.028). BECN1表达与DFS没有显著的关联 (p=0.944).
与光线BC患者 (23.41个月) 相比,三阴BC (TNBC) 病例的DFS率明显较低 (19.0个月) (p=0.022).

结论:

BECN1表达与乳腺癌差异化相关,这表明与疾病的攻击性存在潜在联系.
虽然BECN1水平在这个队列中没有直接预测DFS,但它与更高等级的关联需要进一步调查.
三重阴性乳腺癌仍然是预后不太有利的亚型,这强调了对亚型特定治疗策略的需求.

关键词:

自自是一种自的过程.贝克林 1 贝克林 1 是一个乳腺癌乳腺癌乳腺癌在 DFS DFS 中,

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