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外寄生虫中抗异黄素的抗药机制:一个范围审查
Joanna Furnival-Adams1,2, Caroline Kiuru3,4, André Barembaye Sagna5
1Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. joannafa28@gmail.com.
Parasitology research
|May 24, 2024
概括
外寄生虫中抗 Ivermectin 的机制主要是代谢性的或涉及排泄,对目标部位耐药性的研究有限. 了解这些机制对于ivermectin大规模药物管理计划和开发抗药减缓策略至关重要.
科学领域:
- 寄生虫学的寄生虫学
- 昆虫学 昆虫学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 艾弗梅克丁大规模药物管理 (MDA) 广泛用于对外寄生虫进行控制.
- 艾弗迈克丁正在考虑用于疟疾载体控制,需要了解潜在的耐药性.
- 预测和理解外寄生虫中对ivermectin耐药机制的预测和理解对于公共卫生干预至关重要.
研究的目的:
- 审查和绘制人类和兽医外寄生虫对ivermectin耐药机制的现有证据.
- 确定关于外寄生虫,特别是蚊子对ivermectin耐药性的研究缺口.
主要方法:
- 在PubMed,科学网络和谷歌学者中进行了系统的文献搜索.
- 选了5893份摘要,并提取了关于耐药性类型,方法和遗传位置的数据.
- 叙述总结和表格展示18项已识别的研究的结果.
主要成果:
- 18项研究报告了外寄生虫对ivermectin的耐药性.
- 在16项研究中报告了代谢阻力和改变的排泄表达.
- 只有两项研究描述了目标部位耐药性,对Anopheles spp.的研究有限.
结论:
- 大多数外寄生虫对ivermectin的耐药性涉及代谢机制或排泄活动.
- 关于点耐药性和疟疾载体的耐药性,存在重大知识差距.
- 进一步的研究对于监测ivermectin耐药性和为MDA计划制定有效的缓解策略至关重要.
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