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Updated: Jun 25, 2025

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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在多系统蛋白质病变模型中,VCP激活剂可以逆转核蛋白质稳定缺陷,并增强TDP-43的总体清除

Jessica M Phan, Benjamin C Creekmore, Aivi T Nguyen

    The Journal of clinical investigation
    |May 24, 2024
    PubMed
    概括

    含瓦洛蛋白 (VCP) 的致病变体会导致多系统蛋白质病变 (MSP). 损坏的VCP功能导致核内蛋白质聚合物的积累,这表明VCP激活是潜在的治疗策略.

    关键词:
    遗传性疾病是一种遗传性疾病.神经退行发生神经退行.神经科学是一个神经科学.药理学 药理学是指药理学的学科.治疗方法 治疗方法

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