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Updated: Jun 25, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

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人类DNA拓酶I中毒导致R循环介导的基因组不稳定性,转录因子IIS减弱

Renée C Duardo1, Jessica Marinello1, Marco Russo1

  • 1Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, via Selmi 3, 40126, Bologna, Italy.

Science advances
|May 24, 2024
PubMed
概括

DNA拓酶I (Top1cc) 通过形成DNA-RNA杂交体和微核,可以导致基因组不稳定. 我们发现Top1ccs导致高转录基因的DNA双链断裂,与RNA聚合酶II积累和复制冲突有关.

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