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Updated: Jun 25, 2025

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聚合酶活性位点中的相互作用网络是沃森-克里克基配对在Pol γ中的先决条件

Joon Park1,2, Geoffrey K Herrmann1,2, Arkanil Roy3

  • 1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Science advances
|May 24, 2024
PubMed
概括

DNA聚合酶玛 (Pol γ) arginine-853突变通过破坏活性位点关闭来阻止线粒体DNA复制. 这种结构缺陷解释了Pol γ突变与神经疾病之间的联系.

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