心力衰竭通过天生的免疫记忆促进多病症
Yukiteru Nakayama1, Katsuhito Fujiu1,2, Tsukasa Oshima1
1Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan.
Science immunology
|May 24, 2024
概括
心力衰竭 (HF) 引发了造血干细胞 (HSC) 的变化,导致经常性心脏事件和病等相关疾病. 这些HSCs充当"压力记忆"载体,将HF与并发症联系起来.
科学领域:
- 心血管生物学 心血管生物学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 心力衰竭 (HF) 患者经常经历复发性去补偿,并患上并发性疾病,包括慢性病和脆弱性.
- 关联这些疾病的潜在病理机制尚不清楚.
- 造血干细胞 (HSC) 参与全身炎症和疾病进展.
研究的目的:
- 研究血造干细胞 (HSCs) 在复发性心力衰竭 (HF) 和相关并发症中的作用.
- 阐明心脏压力影响心脏神经关功能和全身健康的机制.
主要方法:
- 在小鼠身上进行骨髓移植实验,以评估HF经历过的HSC的影响.
- 在高频小鼠模型中进行全球色素可访问性分析和单细胞RNA测序 (scRNA-seq).
- 评估转化生长因子-β (TGF-β) 在HSC中的信号传递及其对心脏功能的影响.
主要成果:
- 来自HF小鼠的骨髓诱导了心脏功能障碍,纤维化,并增加了接受者对和肌肉损伤的敏感性.
- HF增强了HSCs产生促炎性巨细胞的能力.
- 来自HF小鼠的HSC中抑制的TGF-β信号与移植后抑制的交感神经活动和加剧的心脏功能障碍相关.
结论:
- 心脏应激在表观遗传上修改了HSCs,改变了它们的巨细胞分化能力.
- 改变的HSC可以通过携带"压力记忆"作为经常性HF事件和并发症的共同驱动因素.
- 准高血压细胞功能障碍为管理高血压及其相关并发症提供了潜在的治疗策略.
相关概念视频
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
421
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
421
Inflammation
53.4K
Overview
53.4K
Heart Failure Drugs: β-Blockers
336
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
336


