与母亲COVID-19疾病严重程度相关的孕产妇和新生儿结局
J Sisman1, E H Adhikari2, L F Black3
1Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA.
Journal of neonatal-perinatal medicine
|May 24, 2024
概括
来自SARS-CoV-2感染的孕产妇疾病严重程度显著影响新生儿的结果,增加早产和NICU入院的风险. 严重的孕产妇疾病也与较高的死亡率相关.
科学领域:
- 围产儿医学 围产儿医学
- 传染性疾病 传染性疾病
- 新生儿科学 新生儿科学
背景情况:
- 周产期的SARS-CoV-2感染对母亲和新生儿的健康构成风险.
- 孕产妇疾病严重程度与具体结果之间的联系需要进一步澄清.
研究的目的:
- 调查母体SARS-CoV-2疾病严重程度与母体/新生儿健康结果之间的关联.
- 分析不同程度的母体COVID-19疾病对分娩和婴儿健康的影响.
主要方法:
- 对 SARS-CoV-2 感染母婴双的回顾性队列研究.
- 数据从2020年3月到2021年12月在一个中心收集.
- 基于母亲疾病严重程度 (无症状,轻度,中度,严重,危急) 的结果分析.
主要成果:
- 患有中度/重度/危急疾病的母亲的诱导率,氧气使用率,机械通风率和ECMO率更高.
- 与无症状或轻度疾病相比,严重的孕产妇疾病与明显更高的死亡率有关.
- 出生于中度/重度/危急疾病的母亲的新生儿更有可能早产,出生体重较低,需要入院于NICU.
结论:
- 在SARS-CoV-2阳性母亲的孕产妇疾病严重程度与孕产妇和新生儿不良结果有显著的关联.
- 增加早产和新生儿重症监护室的入院率与中度至危急的孕产妇疾病严重程度有关.
- 即使是轻微的孕产妇疾病也显示出与NICU入院隔离和降低母乳养率的关联.
更多相关视频
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.8K
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.3K
相关概念视频
01:30Pneumonia III: Complications and Assessment
202
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
202
01:22Development of Immunocompetence
303
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
303
01:28Pneumonia IV: Management
322
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
322
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K