使用OpenFOAM进行冠状动脉血流的计算流体动力学建模:与食品和药物管理基准喷嘴模型进行验证
Sajid Ali1, Chien-Yi Ho2, Chen-Chia Yang3
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Journal of X-ray science and technology
|May 24, 2024
概括
这项研究使用OpenFOAM,一个免费的CFD软件,分析冠状动脉堵塞的血液流动. 它为更好的诊断提供了关于狭窄症严重程度如何影响分数流量储备和壁剪压力的详细见解.
科学领域:
- 心血管研究的心血管研究.
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
背景情况:
- 冠状动脉疾病 (CAD) 是一个主要的全球健康问题.
- 侵袭性冠状动脉血管学具有风险和高成本.
- 非侵入性冠状动脉计算机断层扫描血管造影 (CCTA) 提供了一个更安全的替代方案.
研究的目的:
- 分析冠状动脉中的血液动力学参数,使用患者特定的模型进行连续性狭窄.
- 评估开源CFD软件OpenFOAM对冠状动脉分析的实用性.
- 为了将狭窄症的严重程度与分数流量储备计算断层扫描模拟 (FFRCTS),流体速度和壁剪应力 (WSS) 相对应.
主要方法:
- 从CCTA图像开发出针对患者的3D冠状动脉模型.
- 使用开源CFD软件OpenFOAM进行血液动力学模拟.
- 根据FDA的基准喷嘴模型验证了OpenFOAM.
- 分析了9名患者的17个冠状动脉,评估了不同级别狭窄的FFRCTS,速度和WSS.
主要成果:
- 随着狭窄度的增加,FFRCTS值下降 (级别0的>0.8,级别5的<0.5).
- 随着狭窄的严重程度,中心流体的速度显著增加 (第5级与第1级的3.4倍).
- 3D染可视化了WSS分布,与狭窄症严重程度相关.
结论:
- OpenFOAM为冠状动脉分析提供了商业CFD软件的可靠,具有成本效益的替代方案.
- 将狭窄分级与定量血液动力学参数 (FFRCTS,速度,WSS) 结合起来,可以提高诊断的准确性.
- 这种方法使用3D血液动力学可视化提供了对冠状动脉狭窄的有价值,直观的见解.
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