一种草本适应原料添加剂对慢性循环热应激的与食相关的下丘脑神经的作用
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Updated: Jun 25, 2025

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Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds
Published on: November 6, 2015
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Elizabeth S Greene1, Maryam Afkhami Ardakani1, Sami Dridi1
1Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR, United States.
Neuropeptides
|May 24, 2024
概括
草药适应原剂通过调节参与养调节的下丘脑神经质来改善热应激下的肉生长. 这项研究调查了适应素补充剂对 brojler 料摄入量和热应激期间生长性能的影响.
科学领域:
- 动物科学动物科学
- 营养生理学 营养生理学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 热应激 (HS) 对家禽生产产生负面影响,导致料摄入量减少 (FI),生长受损,死亡率增加.
- 草本适应物是植物提取物,可以增强生物体对环境压力因素的抵抗力.
- 以前的研究表明,在HS条件下,草药适应原剂可以改善 brojler FI 和体重 (BW).
研究的目的:
- 为了调查草本适配原补充剂在暴露于热应激的肉中调节下丘脑与食相关的神经的假设.
- 在热中性和热应激条件下,评估食适应物补充剂对关键神经及其受体在肉下丘脑中的基因表达的影响.
主要方法:
- 雄性Cobb 500肉小被分配到三个饮食组:对照组 (C) 和两个补充草本适配原的饮食 (NR-PHY-500,NR-PHY-1000).
- 鸟类在环境室中养,其中9个室从第29天到第42天受到循环热应激 (35°C每天8小时),而3个室保持温度中立 (24°C).
- 对神经Y (NPY) 受体,皮质激素释放激素 (CRH),黄素受体1 (ORXR1),黑色皮质受体 (MC1R,MC4R,MC5R),维斯法丁和神经分泌蛋白GL (NPGL) 的下丘脑基因表达进行了42日热应激暴露前和后的分析.
主要成果:
- 适应剂补充剂显著上调NPY受体Y4和Y7,CRH,ORXR1,MC1R,MC4R,MC5R,维斯法丁和NPGL基因的下丘脑表达.
- 在热后压力阶段,MC2R的表达上调,这表明了特定时期的反应.
- 对于下丘脑内甲氧素和阿迪波内克丁的表达,观察到期间和治疗之间的显著相互作用,这表明复杂的调节机制.
结论:
- 用草药适应原体的食补充剂可以调节肉中的下丘脑神经基因表达.
- 这些神经化学变化很可能是导致热应激肉的料摄入量和生长性能有所改善的原因.
- 在料中补充适应物是一种可行的策略,可以通过神经内分泌通路减轻家禽生产中热应激的不良影响.
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