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美国鼻状细胞癌:与HPV检测和阳性相关的时间和地理模式

Andrea Costantino¹, Bruce Haughey², Jianbin Zhu³

¹Department of Otolaryngology - Head and Neck Surgery, AdventHealth Orlando, 410 Celebration Place, Celebration, FL 34747, United States.

|May 24, 2024

概括

人类乳头瘤病毒 (HPV) 检测在鼻腔状细胞癌 (SNSCC) 病例中减少,但HPV阳性瘤增加,特别是在白人患者中. 测试中的差异凸显了SNSCC中HPV标准化方案的需要.

科学领域:

在瘤学瘤学.
病毒学病毒学
流行病学流行病学

背景情况:

人类乳头瘤病毒 (HPV) 与鼻腔状细胞癌 (SNSCC) 有关.
了解SNSCC的HPV患病率和时间趋势对于诊断和治疗至关重要.
目前关于HPV在SNSCC时间模式和人口统计中的作用的数据有限.

研究的目的:

调查HPV测试的时间趋势和SNSCC中的阳性率.
探索影响SNSCCHPV趋势的人口和地理因素.
为了评估HPV和SNSCC之间随着时间的推移的联系.

主要方法:

使用美国国家癌症数据库 (NCDB) 进行的回顾性队列研究.
包括在2011年至2017年期间被诊断患有侵入性SNSCC的患者.
估计HPV阳性和测试率的患病率 (PR) 和95%置信区间 (CI) 的测试率.

主要成果:

总体HPV检测率为45.4%,在研究期间显著下降 (aPR:0.97).
总体HPV阳性为37.3%,随着时间的推移显著增加 (aPR:1.04).
仅在白人人口中观察到HPV阳性率的上升,测试和阳性率的地理差异很大.

结论:

时间趋势显示HPV测试减少,但在SNSCC中HPV阳性增加.
在HPV检测率的差异仍然存在,特别是在人口和地理方面.
标准化检测协议和有针对性的干预措施是必要的,以解决HPV在SNSCC.

关键词:

生物标志物生物标志物流行病学流行病学人类乳头瘤病毒的人类乳头瘤病毒流行程度流行程度风险因素风险因素鼻质新生体.

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