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新型延长释放的超皮制剂的迷幻N,N-二甲基胺 (DMT)
Christopher G Witowski1, Mika R Hess2, Nate T Jones2
1Psilera Inc., 3802 Spectrum Blvd., Suite 136B, Tampa, FL 33612, United States.
概括
一个新的透皮N,N-二甲基三胺 (DMT) 贴片提供了一个安全的,可访问的,非幻觉性迷幻疗法选择. 这种新的输送系统显示出高生物可用性和延长释放,用于潜在的门诊抑郁症治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 神经科学是一个神经科学.
背景情况:
- N,N-二甲基三胺 (DMT) 显示了抑郁症的治疗潜力,但由于服用方法和高剂量,它面临着可访问性挑战.
- 由于DMT的快速代谢降解,需要侵入性静脉注射 (IV),在强烈的主观影响期间存在风险.
- 低于幻觉的DMT剂量可能足以产生治疗效益,这表明需要使用替代的输送方法.
研究的目的:
- 开发和评估用于DMT输送的非侵入性皮肤间药物粘合贴.
- 评估体内通过皮肤DMT的安全性,药理动力学概况和生物可用性.
- 探索非幻觉,门诊类迷幻疗法的潜力.
主要方法:
- 用各种粘合剂和透增强剂对DMT通过皮肤贴片的配方开发和体外测试.
- 在小鼠中进行补丁配方 (F5) 的体内药理动力学和行为研究.
- 使用LC/MS/MS对血和大脑样本中的DMT水平的量化,并通过头测试评估幻觉效应.
主要成果:
- 通过皮肤注射的DMT贴片 (F5) 在非幻觉性血度 (不超过60 ng/mL) 时提供一致的,延长的药物释放.
- 通过皮肤给药将DMT的IV半衰期延长了20倍,并且与IV给药相比,证明了77%的生物可用性.
- 行为测试证实,在通过皮肤系统实现的低血水平下,幻觉不存在.
结论:
- 通过皮肤输送DMT是一种可行的,非侵入性的方法,可以在没有幻觉的情况下达到治疗药物水平.
- 这种透皮系统为门诊心理治疗提供了一个有前途的替代方案,特别是对于不需要高剂量玻尿酸剂量的指示.
- 开发的透皮DMT贴片增强了药物的生物可用性,并延长了半衰期,解决了现有药物管理途径的关键局限性.
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