长期暴露于消毒剂对肠道免疫力和草鱼微生物群的变异产生影响
Fei Shi1, Lixin Ma1, Zhilong Chen1
1Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China.
Aquatic toxicology (Amsterdam, Netherlands)
|May 24, 2024
概括
消毒剂如甲基和波维对草的肠道健康有害,因为它们减少了微生物的多样性,抑制了免疫力,并增加了肠道细胞死亡. 这项研究揭示了常见水生消毒剂对鱼类健康的负面影响.
科学领域:
- 水生物质毒理学研究
- 鱼类免疫学 鱼类免疫学
- 微生物组研究的研究.
背景情况:
- 肠道微生物组对于鱼类健康平衡至关重要.
- 消毒剂在水产养殖中使用,但它们对健康鱼的肠道健康的影响尚不清楚.
研究的目的:
- 研究甲基和波维对草肠道微生物群,免疫反应和肠道完整性的影响.
- 了解消毒剂对鱼类健康的影响.
主要方法:
- 草被暴露在甲基 (80微克/升) 或波维- (50微克/升) 中四周.
- 进行了转录组分析,16S rDNA高通量测序,组织病理学和亡检测.
主要成果:
- 消毒剂诱导了肠道抗氧化系统,并抑制了消化酶功能.
- 肠道微生物多样性下降,与免疫相关的途径发生变化,炎症和紧结基因的表达受阻.
- 消毒剂暴露损害了肠道的结构完整性,并促进了亡.
结论:
- 长期接触消毒剂会降低氧化抵抗力,并抑制草的免疫反应.
- 消毒剂会引起肠道失生症,并增加鱼肠中的亡.
- 这些发现凸显了消毒剂对水产养殖健康的潜在风险,并表明需要谨慎管理.
相关概念视频
01:29Bacterial Flora of the Large Intestine
422
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
422
01:23Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K