老年人听力能力和皮质形态之间的关联:多参数映射,认知相关性和神经生物学基础
Xiaofan Qiu1, Jing Yang2, Xin Hu2
1Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, China.
EBioMedicine
|May 24, 2024
概括
老年人听力不佳与皮层厚度和折叠率的降低有关. 这些大脑变化可能解释了听力损失和认知衰退之间的联系,具有明显的神经生物学基础.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 听力学 听力学是指听力学.
背景情况:
- 听力障碍在老年人群中很普遍.
- 与年龄相关的听力损失的神经相关性需要进一步阐明.
研究的目的:
- 调查老年人听力能力和大脑结构之间的关系.
- 探索皮层形态学在听觉认知联系中的调解作用.
- 识别与听觉相关的大脑变化相关的神经生物学基质.
主要方法:
- 在284名老年人身上进行了结构核磁共振,磁共振光谱和听力测量.
- 皮层形态指数 (厚度,旋转) 与纯色调平均值 (PTA) 相相关.
- 调解分析检查了皮质区域在听觉认知关系中的作用,与连接性,转录性和神经递质数据相关.
主要成果:
- 听力较差与全球皮质厚度降低和特定区域的化降低相关 (右52区域,岛屿颗粒复合物).
- 在右侧52区的化调解了听力能力和执行功能之间的关联.
- 神经递质水平 (谷氨酸,N-乙酸,多巴胺,血清素) 和基因表达模式与这些结构变化有关.
结论:
- 与年龄相关的听力损失与皮质厚度和折叠的显著减少有关.
- 这些结构性大脑变化可能会影响听力损失对老年人认知功能的影响.
- 截然不同的神经生物学因素是听力,大脑结构和认知之间观察到的关联的基础.
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