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Updated: Jun 25, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

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针对性地拯救突触可塑性改善了毒症相关脑病变的认知衰退

Benedikt Grünewald1, Jonathan Wickel2, Nina Hahn2

  • 1Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany; Section Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany; Institute of Pathophysiology and Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Molecular therapy : the journal of the American Society of Gene Therapy
|May 24, 2024
PubMed
概括

败血症相关脑病变 (SAE) 通过损害大脑突触导致长期的认知问题. 通过基因疗法或环境丰富恢复突触功能,可以改善SAE模型中的记忆和突触可塑性.

关键词:
由AAV介导的过度表达.这就是 ARC ARC.这就是为什么BDNF是BDNF.丰富的环境丰富的环境在海马体内,海马体记忆功能障碍 记忆功能障碍败血症相关的脑病变突触性可塑性 突触性可塑性

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