在中枢神经系统癌症和周围癌症中TREM2的不同作用

Jian Zhong1, Xudong Xing2, Yixin Gao1

  • 1Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China.

Cancer cell
|May 24, 2024
PubMed
概括

在骨髓细胞-2 (TREM2) 上表达的触发受体在质母细胞瘤 (GBM) 中具有免疫保护作用,与外周癌症不同. 较低的TREM2水平与瘤进展和免疫抑制的增加相关,这表明TREM2是脑瘤的潜在治疗标.

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