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肝癌的异质性免疫微环境:新兴的单细胞和空间视角

Caiyi Cherry Li¹, Meng Liu¹, Hsin-Pei Lee¹

¹Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Seminars in liver disease

|May 24, 2024

概括

了解肝瘤免疫微环境 (TIME) 是改善癌症免疫疗法的关键. 本综述探讨了细胞相互作用和奥米克技术,以推进肝癌治疗策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

原发性肝癌的死亡率很高.
免疫疗法是有前途的,但需要对瘤免疫微环境 (TIME) 有更深入的了解.

研究的目的:

通过使用单细胞和空间奥米克,回顾肝脏的细胞格局.
讨论肝脏瘤微环境中的细胞相互作用.
突出改善肝癌免疫疗法的挑战和机遇.

主要方法:

综述了单细胞和空间欧米茄技术的最新进展.
系统生物学方法应用于瘤免疫学.
肝脏细胞相互作用网络的分析时间.

主要成果:

从单细胞和空间角度详细审查肝脏细胞组成的时间.
讨论调节瘤内的免疫反应的关键细胞相互作用.
识别现场挑战和机遇.

结论:

欧米克和系统生物学方面的进步正在改变肝脏的研究.
了解肝脏时间对于开发有效的生物标志物,患者分层和组合免疫疗法至关重要.

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...