相关实验视频

Updated: Jun 25, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

在治疗耐药抑郁症的rTMS期间自杀念头的轨迹

Denghuang Zhan¹, Elizabeth C Gregory², Afifa Humaira²

¹Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; Centre for Advancing Health Outcomes, St Paul's Hospital, Vancouver, BC, Canada; School of Population & Public Health, University of British Columbia, Vancouver, BC, Canada.

Journal of affective disorders

|May 24, 2024

概括

低频重复性横磁性刺激 (rTMS) 在大多数治疗耐药抑郁症患者中改善了自杀念头 (SI). 然而,更高的基线焦虑是SI和情绪改善预后不佳的预测因素.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
临床心理学临床心理学

背景情况:

重复性横磁性刺激 (rTMS) 是一种已被公认的治疗治疗耐药性抑郁症 (TRD) 的方法.
关于rTMS在治疗期间对自杀念头 (SI) 的特定影响和反应轨迹的数据有限.

研究的目的:

调查TRD患者接受低频rTMS (LFR) 的自杀念头 (SI) 结果和响应轨迹.
识别与不同SI和情绪反应轨迹相关的风险因素.

主要方法:

一项开放的临床试验,涉及55名TRD患者,这些患者接受了LFR到右背侧前额皮层 (DLPFC).
隐藏类混合效应建模以确定SI和情绪症状轨迹.
后勤回归分析以确定已识别的轨迹的风险因素.

主要成果:

对SI和情绪观察到两个不同的轨迹:改善和没有改善.
60%的患者表现出SI的改善,53%的患者表现出情绪的改善.
较高的基线焦虑,男性性别和较高的基线SI预测了较差的SI结果. 较高的基线焦虑和二胺使用预测了较差的情绪结果.

结论:

这项研究是首次检查右DLPFC对LFR的响应轨迹.
虽然LFR在大多数TRD患者中改善了SI和情绪,但焦虑严重程度成为预后不佳的重要预测因素.
了解微妙的SI反应模式可以为个性化的RTMS治疗策略提供信息.

关键词:

低频rTMS的使用情况右边的DLPFCFC是右边的DLPFC.自杀的想法自杀的想法症状的发展轨迹症状的发展轨迹治疗耐药性抑郁症的治疗方法

更多相关视频

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

相关概念视频

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...