大型抑郁症和甲状腺疾病之间的因果关系:孟德尔的随机化研究和调解分析
Xu Zhang1, Qiao Lu1, Yiping Luo1
1Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China.
Journal of affective disorders
|May 24, 2024
概括
大型抑郁症 (MDD) 与欧洲祖先的甲状腺功能低下症,甲状腺功能过高症和哈希莫托甲状腺炎风险增加有关. 酒精摄入量和抗抑郁药的使用可能会在患有抑郁症的人中调解这些甲状腺疾病.
科学领域:
- 遗传学和流行病学
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 抑郁症和甲状腺疾病之间的关系是复杂的,并未完全理解.
- 以前的研究表明存在联系,但缺乏因果关系的证据.
研究的目的:
- 通过使用孟德尔随机化来调查主要抑郁症 (MDD) 和甲状腺疾病/功能之间的因果关系.
- 在这种关联中,探索潜在的调解者,如酒精摄入量和抗抑郁药的使用.
主要方法:
- 两个样本的孟德尔随机化分析使用来自欧洲和东亚祖先的全基因组关联研究总结统计数据.
- 研究了MDD与各种甲状腺结局 (甲状腺功能低下,甲状腺功能过高,哈希莫托甲状腺炎,甲状腺功能标志物) 之间的关联.
- 用调解分析来评估酒精摄入量和抗抑郁药使用的作用.
主要成果:
- 在欧洲祖先中发现了MDD与甲状腺功能低下症,甲状腺功能过高症和哈希莫托甲状腺炎风险增加之间存在显著的因果关系.
- 酒精摄入量和抗抑郁药的使用被确定为欧洲祖先的甲状腺功能低下症和哈希莫托甲状腺炎的显著调解者.
- 在东亚祖先中,没有观察到MDD和甲状腺疾病/功能之间的显著因果关系.
- 在任何一个祖先群体中都没有发现甲状腺功能和MDD之间的双向因果关系的证据.
结论:
- 在欧洲祖先的个体中,MDD与特定甲状腺疾病的风险增加有关.
- 酒精摄入量和抗抑郁药的使用可能在患有MDD的人群中在这些甲状腺疾病的发展中发挥中介作用.
- 调查结果突出了干预和预防战略的潜在目标.
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