作为潜在的益生菌来缓解性结肠炎的Astragalus多糖的功能分数
Zeqi Huo1, Junxiang Li1, Xiaofeng Li1
1School of Life Sciences, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, Lanzhou University, Lanzhou 730000, China; Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, Lanzhou University, Lanzhou 730000, China.
阿斯特拉加勒斯的多糖 (APS) 在性结肠炎 (UC) 中表现有前途. 低分子量APS1有效降低了炎症并改善了肠道健康,突出了其作为UC新型益生菌治疗的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 性结肠炎 (UC) 是一种与肠道失调相关的慢性肠道炎症疾病.
- 阿斯特拉加卢斯膜的多糖 (APS) 已经证明了对UC的治疗潜力,但活性成分和机制需要澄清.
研究的目的:
- 在UC模型中研究两个APS分数 (APS1和APS2) 的益生菌效应和治疗机制.
- 确定在改善UC症状方面具有卓越功效的特定APS分量.
主要方法:
- 通过超过来分离APS分数 (APS1: Mw < 10 kDa,APS2: 10 kDa < Mw < 50 kDa) 的方法.
- 在硫酸盐 (DSS) 诱导的UC小鼠模型中评估益生菌性质和疗效.
- 评估结肠病理,炎症标志物,肠道屏障完整性,微生物组成和短链脂肪酸生产.
主要成果:
- 无论是APS1还是APS2,都表现出了益生菌的特性,其中APS1的疗效显著提高.
- APS1减轻了体重减轻,减少了结肠炎症和病理,增强了肠道屏障功能.
- APS1调节了血清和结肠炎症性细胞因子和化学因子,纠正了DSS诱导的失生症,增加了短链脂肪酸.
结论:
- 阿斯特拉加勒斯的多糖,特别是低分子量分数APS1,具有显著的益生菌效应.
- 通过调节肠道微生物群和减少炎症,APS1显示出预防和治疗性结肠炎的强大治疗潜力.
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