来自单个原核的胚胎适合于植入前遗传测试
Oshrit Lebovitz1, Meirav Noach-Hirsh1, Sarah Taieb1
1Department of Obstetrics and Gynecology, IVF Unit, Chaim Sheba Medical Center, Tel- Hashomer, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Fertility and sterility
|May 24, 2024
概括
单核 (1PN) 胚胎的发育和PGT-M成功率低于双核 (2PN) 胚胎. 然而,1PN胚胎仍然可以产生成功的怀孕和PGT-M的活产,改善整体率.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
- 胚胎学 胚胎学
背景情况:
- 对单一性疾病的植入前遗传检测 (PGT-M) 对于预防遗传性疾病至关重要.
- 胚胎发育和活力可以根据前核数 (1PN与2PN) 不同.
研究的目的:
- 为了比较从单个原核 (1PN) 和两个原核 (2PN) 获得的胚胎之间的PGT-M结果和治疗结果.
- 评估PGT-M在1PN胚胎中的临床实用性.
主要方法:
- 351个IVF-PGT-M周期 (2018年1月-2022年12月) 的回顾性队列研究.
- 对1PN和2PN衍生胚胎的胚胎活检,分子测试和临床结果的分析.
- 胚胎囊发育率和PGT-M成功率的比较.
主要成果:
- 与2PN胚胎相比,1PN胚胎具有显著较低的发育潜力,具有较少的胚芽细胞和最高质量的胚芽细胞.
- PGT-M成功率 (未受影响的胚胎) 在1PN (47.1%) 与2PN (65.5%) 相比较低,在1PN (39.6%) 中异常结果较高.
- 尽管比率较低,但1PN胚胎移植导致了20.8%的临床怀孕和16.7%的活产率.
结论:
- 虽然1PN胚胎减少了发育潜力和PGT-M成功,但它们仍然可以导致成功怀孕.
- 建议将PGT-M应用于1PN胚胎,以提高试管婴儿治疗中的累积临床怀孕和活产率.
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