癌症中的微生物组:人类和狗之间的比较分析
Dell'Anno Filippo1, Lisa Guardone2, Valeria Listorti2
1National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Genova 16129, Italy; Department of Public Health, Experimental and Forensic Medicine, Section of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy.
Veterinary journal (London, England : 1997)
|May 24, 2024
概括
狗癌症研究提供了对人类疾病的见解,这是由于共享的生物学和环境. 狗和人类的微生物组失调与癌症的发展和治疗反应有关,突出了比较性瘤学研究.
科学领域:
- 比较性瘤学研究
- 微生物组研究的研究.
- 狗和人类癌症研究的研究.
背景情况:
- 癌症是全球主要的死亡原因,需要对风险因素和治疗方法进行研究.
- 由于基因组和免疫学相似之处,自发性犬类瘤可以作为人类瘤疾病的有价值模型.
- 狗共享环境因素,并且与人类比小鼠模型更具同源性微生物组.
研究的目的:
- 审查和组织有关狗微生物组组合的当前信息.
- 研究狗微生物组与结直肠,乳腺癌和淋巴瘤之间的关系.
- 为了比较有关微生物组影响的狗和人类癌症的发现.
主要方法:
- 关于狗微生物组和癌症的已发表研究的文献综述.
- 分析与大肠直肠癌,乳腺癌和狗淋巴瘤相关的微生物组数据.
- 狗的发现与现有的人类微生物组癌症研究的比较.
主要成果:
- 狗和人类的抗生素或微生物不平衡与炎症有关,可以促进癌症的发展,特别是在肠道.
- 微生物组的改变可以影响癌症治疗的有效性和副作用,在两种物种.
- 关于狗淋巴瘤和乳腺癌微生物组的研究有限,这表明需要进一步调查.
结论:
- 对狗的研究对于理解比较瘤学和微生物群在癌症中的作用至关重要.
- 微生物组失生症是癌症发病,进展和治疗反应在狗和人类中的重要因素.
- 对狗淋巴瘤和乳腺癌微生物组的进一步研究对于进一步了解这些疾病至关重要.
相关概念视频
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
01:50What is Monogastric Digestion?
71.1K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.1K