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Updated: Jun 25, 2025

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通过无意中介的mRNA衰变微调化粉样蛋白前体蛋白表达

Maryam Rahmati1, Jasmine Chebli1, Rakesh Kumar Banote1

  • 1Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.

eNeuro
|May 24, 2024
PubMed
概括

粉样蛋白前体蛋白基因中的遗传突变触发了转录适应 (TA) 进行补偿. 这涉及无意义介导的mRNA衰变 (NMD) 和斑马鱼和人类细胞中的同源基因激活.

关键词:
这是一个NMD.在Upf1上.粉样蛋白前体蛋白质的前体蛋白质是什么一个突变的突变者.转录适应的转录适应斑马鱼是一种斑马鱼.

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