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Updated: Jun 25, 2025

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对于通过DREAM和E2F:RB复合体抑制细胞循环基因,HDAC活性是不可或缺的

Alison K Barrett1, Manisha R Shingare1, Andreas Rechtsteiner2

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA.

Nature communications
|May 24, 2024
PubMed
概括

基因组脱乙酶 (HDACs) 不是细胞循环基因抑制的必要条件. 梦想和视网膜母细胞瘤 (RB) 综合体可以在没有HDAC的情况下使基因沉默,挑战了以前的细胞周期控制模型.

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