促进 propionic 酸生产的肠道微生物群伴随着热量限制引起的猫的故意体重减轻
J C Rowe1,2, J A Winston3,4, V J Parker1,2
1Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, OH, USA.
Scientific reports
|May 24, 2024
概括
体重减轻的肥胖猫在肠道细菌中出现了显著的变化,增加了酸的产生. 这表明肠道微生物群和猫科动物的体重管理之间存在联系,类似于人类.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 来自肠道微生物群的短链脂肪酸 (SCFA) 与人类和动物的肥胖和胰岛素抵抗有关.
- 在猫肥胖中SCFA的作用,这是美国普遍存在的问题,仍未得到充分研究.
研究的目的:
- 研究热量限制引起的体重减轻对肥胖猫的肠道微生物群和SCFA概况的影响.
- 探索特定微生物种群与猫在减肥期间SCFA产生的潜在相关性.
主要方法:
- 超重/肥胖的猫 (n=7) 接受了多阶段的饮食干预,包括减少卡路里和维持饮食.
- 用16S rRNA基因安普利康序列和向的SCFA代谢学分析了便样本.
- 使用统计分析,包括PERMANOVA和重复测量相关性,以评估微生物和代谢变化.
主要成果:
- 卡路里限制导致猫的有意减肥显著 (调整后p < 0.0001).
- 便微生物群落结构在研究阶段有显著差异 (PERMANOVA p = 0.011).
- 在卡路里限制诱导的体重减轻期间,便中的酸水平显著上升 (调整后p < 0.05),与Prevotella 9 copri的丰度相关.
结论:
- 肥胖猫在减肥期间表现出改变的肠道微生物结构和功能,反映了人类的发现.
- 该研究强调了肠道微生物群,特别是酸生产在猫体重管理中的作用.
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