Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

19.0K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
19.0K
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

6.3K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
6.3K
Effects of feedback01:24

Effects of feedback

548
Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
548
Negative Regulator Molecules01:23

Negative Regulator Molecules

35.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.3K
Feedback Inhibition00:46

Feedback Inhibition

53.8K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
53.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.

Cell genomics·2026
Same author

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.

Nature·2026
Same author

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation.

Science (New York, N.Y.)·2025
Same author

The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.

Developmental cell·2024
Same author

Comparison of the efficacy of ultrasound guided pectoralis-II block and intercostal approach to paravertebral block (proximal intercostal block) among patients undergoing conservative breast surgery: A randomised control study.

Journal of anaesthesiology, clinical pharmacology·2023
Same author

Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program.

Science translational medicine·2023

相关实验视频

Updated: Jun 25, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.4K

一个负反循环是华堡效应的基础.

Alok Jaiswal1, Raghvendra Singh2

  • 1Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, India.

NPJ systems biology and applications
|May 24, 2024
PubMed
概括

癌细胞使用有氧糖解 (华堡效应) 进行增殖. 这项研究揭示了一个负反循环,解释了华堡效应及其在癌症干细胞静止和增殖中的作用.

科学领域:

  • 生物化学 生物化学
  • 癌症生物学 癌症生物学
  • 细胞代谢 细胞代谢

背景情况:

  • 有氧糖解 (Warburg效应) 对癌细胞增殖至关重要,但其与氧化酸化和增殖的联系尚不清楚.
  • 乳酸生产与癌症的进展有关,因此需要更深入地了解癌细胞中的代谢调节.

研究的目的:

  • 阐明华堡效应背后的机制及其在癌细胞增殖中的作用.
  • 研究有氧糖解,氧化酸化和癌症干细胞静止之间的关系.
  • 探索癌细胞在缺氧的代谢适应.

主要方法:

  • 研究了负反循环 (NFL) 在有氧糖解中的作用.
  • 分析了有氧糖解和氧化酸化之间的相互作用.
  • 研究了癌症干细胞静止的代谢要求.

主要成果:

  • 负反循环 (NFL) 被确定为华堡效应的驱动因素.
  • 氧化糖解作为氧化酸化的放大剂.
  • 有氧糖解和氧化酸化都能协同促进癌症干细胞静止.

结论:

  • 这些发现澄清了华堡效应的机制及其在扩散和静止中的双重作用.

更多相关视频

Saccharomyces cerevisiae Exponential Growth Kinetics in Batch Culture to Analyze Respiratory and Fermentative Metabolism
07:38

Saccharomyces cerevisiae Exponential Growth Kinetics in Batch Culture to Analyze Respiratory and Fermentative Metabolism

Published on: September 30, 2018

42.0K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K

相关实验视频

Last Updated: Jun 25, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.4K
Saccharomyces cerevisiae Exponential Growth Kinetics in Batch Culture to Analyze Respiratory and Fermentative Metabolism
07:38

Saccharomyces cerevisiae Exponential Growth Kinetics in Batch Culture to Analyze Respiratory and Fermentative Metabolism

Published on: September 30, 2018

42.0K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
  • 了解这些代谢途径为癌症进展,细胞循环调节和干性提供了见解.
  • 这项研究强调了针对癌症治疗的代谢途径的潜力.