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暴露于母体SARS-CoV-2在子宫内的儿童的神经发育延迟

Viviana Fajardo-Martinez¹, Fatima Ferreira², Trevon Fuller³

¹David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.

Scientific reports

|May 24, 2024

概括

在怀孕期间暴露于SARS-CoV-2感染的儿童显示出明显更高的发育延迟频率. 产前COVID-19暴露需要对婴儿进行神经发育的随访.

科学领域:

儿科神经发育儿童神经发育
传染性疾病传染性疾病
孕产妇健康孕产妇健康

背景情况:

怀孕期间的SARS-CoV-2感染对婴儿神经发育的影响在很大程度上是未知的.
评估潜在的长期影响对于理解和管理与产前病毒暴露相关的风险至关重要.

研究的目的:

为了评估婴儿神经发育结果在婴儿暴露于SARS-CoV-2在子宫内.
将这些结果与大流行前的对照组进行比较.

主要方法:

使用贝利婴儿和幼儿发育尺度,第三版 (贝利-III) 和年龄和阶段问卷 (ASQ-3) 进行神经发育评估.
在怀孕期间暴露于SARS-CoV-2的172名婴儿与来自洛杉矶和里约热内卢的128名未暴露的对照婴儿进行了比较.
定义的发育迟缓 (DD) 基于在贝利-III上低于-2 SD或在ASQ-3上低于切断线的标准化得分.

主要成果:

与对照组 (1.6%) 相比,暴露于子宫内SARS-CoV-2的婴儿表现出明显更高的发育延迟发病率 (11.6%).
具体发现显示,暴露的DD为9.4%,对比Bayley-III对照的1.6%,以及里约热内卢的12%对比2.6%.
怀孕期间严重或危急的母体COVID-19与暴露婴儿的神经发育结果较差有关 (OR 2.6).

结论:

暴露于子宫内SARS-CoV-2感染的儿童显示发育延迟的频率增加了十倍.
应考虑对产前COVID-19暴露的婴儿进行常规的神经发育随访.
产前暴露于SARS-CoV-2对婴儿神经发育不良结果构成重大风险.

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