陈旧的有色素和非有色素弹性体的生物相容性概况,用于结合的面缺陷
Eman M Saleh1, Faten S Mohamed1, Radwa A Mehanna2
1Department of Prosthodontics, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
概括
在面假肢中使用的酸弹性体A-2000在加速衰老后显示出可接受的生物相容性. 定期评估对于及时更换来管理细胞毒性反应至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 组织工程是组织工程.
背景情况:
- 面假肢对于恢复功能和美观至关重要.
- 色弹性体A-2000是这些设备的常见材料.
- 了解老化后的材料生物相容性对于患者安全至关重要.
研究的目的:
- 为了评估老白金弹性体A-2000的生物相容性.
- 评估对人类皮肤和牙纤维细胞的细胞毒性.
- 为了确定加速衰老对材料性能的影响.
主要方法:
- 室温化板样品经过老化,以模拟口内和口外条件.
- 人体皮肤和牙纤维细胞被暴露在提取物中.
- 用MTT测定法测量细胞毒性.
- 统计分析包括单向ANOVA.
主要成果:
- 与对照组相比,老化色素的细胞毒性增加.
- 非颜色在48小时后表现出细胞毒性.
- 牙纤维细胞被老化和非老化提取物敏感化.
- 皮肤细胞的生长与暴露有负相关性,而衰老的影响最小.
结论:
- 在老化后,制弹性体A-2000在临床限制内显示出可接受的生物相容性.
- 建议定期评估面假肢.
- 材料老化可能会影响细胞毒性反应,需要及时更换.
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