胚胎大脑发育的分子调节在内生和先天性老鼠菌株中,长寿不同
Maliha Islam1, Susanta K Behura1,2,3,4
1Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.
Genes
|May 25, 2024
概括
发育中的胎儿大脑中的基因调节在不同寿命的小鼠菌株之间有所不同. 胎儿大脑发育中的表观遗传变化与长寿有关,这表明其起源于早期的生活.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 长寿在不同的老鼠菌株之间有很大的差异.
- 胎儿大脑发育是一个由遗传和环境因素影响的关键时期.
- 表观遗传机制在调节基因表达和细胞衰老方面发挥着作用.
研究的目的:
- 研究不同寿命的小鼠发育中的胎儿大脑中的基因调控和替代拼接.
- 通过分析胎儿大脑中的DNA甲基化模式来探索长寿的表观遗传基础.
- 为了确定大脑中早期的表观遗传修饰是否与寿命有关.
主要方法:
- 长寿 (C57BL/6J) 和短寿 (B6.Cg-Cav1tm1Mls/J,AKR/J) 小鼠在妊娠12日,15日和17日的胎儿大脑中的全基因表达和替代拼接变体分析.
- 在第15天使用胎儿大脑DNA甲基化数据进行表观遗传时钟分析.
- 基因表达模式和甲基化位点在具有相反寿命的菌株之间进行比较.
主要成果:
- 从怀孕第15天开始,在短寿命和长寿命小鼠之间观察到与大脑发育,衰老和替代拼接相关的基因表达显著差异.
- 在第15天与第12天和第17天相比,观察到支链变异的应变依赖性减少.
- 15日胎儿大脑中的DNA甲基化模式与单核酸多态性和与年龄相关的表观遗传变化有关,将表观遗传修饰与寿命联系起来.
结论:
- 胎儿大脑发育和寿命在表观遗传上是相互关联的.
- 大脑中早期的表观遗传修饰可能有助于确定寿命.
- 这项研究支持了长寿的早期生命起源的概念.
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