血红素预测急性缺血性中风或过渡性缺血性发作患者的预后不佳
Lingyun Cui1, Yefang Feng2, Ping Lu1
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Brain sciences
|May 25, 2024
概括
血红素 (HCT) 水平预测了急性缺血性中风 (AIS) 和短暂缺血性发作 (TIA) 患者的结果. 低HCT和高HCT都与不良功能结果和死亡风险的增加有关.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 急性缺血性中风 (AIS) 和短暂性缺血性中风 (TIA) 是致病率和死亡率的重要原因.
- 确定AIS/TIA患者不良结果的可靠预测因素对于及时干预至关重要.
- 血红素水平 (HCT) 是红细胞体积的衡量标准,可能在中风病理生理学和结果中发挥作用.
研究的目的:
- 研究诊断为急性缺血性中风 (AIS) 或短暂缺血性发作 (TIA) 的患者的基线血红素 (HCT) 水平和不良临床结果之间的关联.
- 为了确定HCT水平是否可以作为一个可预测的标记,用于功能不良的结果,所有原因的死亡,中风复发,和血管事件在事件后三个月内.
主要方法:
- 分析了中国国家中风登记-III的14832名被诊断患有AIS或TIA的参与者的数据.
- 参与者根据他们的基线HCT水平分为四分之一.
- 使用后勤和考克斯回归模型来评估HCT四分位数与结果之间的关系,并对潜在的混因素进行调整.
主要成果:
- 与第三个四分位数 (调整后OR: 1.35) 相比,在最低的HCT四分位数中的患者表现出明显增加的功能性结果差的风险 (修改的兰金尺度≥3).
- 最低和最高的HCT四分位数都与更高的全因死亡风险有关 (调整后的HR分别为1.68和2.02).
- 敏感性分析证实了HCT与功能表现不佳的关联,而其与全因死亡的联系在排除复发性中风患者时显示出了变化.
结论:
- 基线血红素 (HCT) 水平与AIS或TIA患者的短期不良结果显著相关.
- 非常低和非常高的HCT水平都可能表明功能恢复和死亡率低下的风险增加.
- HCT水平成为潜在的,易于获得的生物标志物,用于预测中风和TIA急性阶段的结果.
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