儿童和青少年有功能性体力障碍的炎症标志物:系统性审查
Anne Sofie Hansen1,2, Charlotte Ulrikka Rask3,4, Karen Hansen Kallesøe3,4
1Department of Child and Adolescent Psychiatry, Aalborg University Hospital, 9000 Aalborg, Denmark.
Children (Basel, Switzerland)
|May 25, 2024
概括
低度炎症可能导致儿科功能性体力障碍 (FSD). 这次审查发现,在患有FSD的儿童中,IL-6和TNF-α等炎症标志物升高,这表明它在疾病发展中的作用.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 儿童和青少年精神病学 儿童和青少年精神病学
背景情况:
- 功能性体力障碍 (FSD) 在儿科患者中很普遍.
- 新出现的证据表明,低度炎症与儿科FSD的发展/维持之间存在联系.
研究的目的:
- 系统地审查调查儿童和青少年FSD系统性炎症标志物的研究.
- 为了比较儿科FSD患者和健康对照者之间的炎症标志物水平.
主要方法:
- 系统的文献搜索产生了1374篇文章;15项研究符合纳入标准.
- 在696名儿童和青少年中分析了41种血清/血细胞因子.
- 在FSD患者的炎症标志物水平与对照者的比较.
主要成果:
- 十二项研究报告了儿科FSD患者细胞因子水平的变化.
- 九项研究发现显著增加了特定细胞因子 (例如IL-6,CRP,TNF-α) 的水平.
- 三项研究发现,群体之间的炎症标志物没有显著差异.
结论:
- 炎症反应可能在儿科FSD的病理生理学中发挥作用.
- 包括的研究有局限性 (质量,样本大小,FSD频谱),限制了概括性.
- 建议进行纵向研究,以进一步调查炎症标志物和儿科FSD之间的联系.
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