产前维生素B12和儿童的大脑发育以及认知,语言和运动结果:一个范围广泛的审查
Fasika Jembere1, Deborah Dewey2,3,4,5
1Undergraduate Medical Education, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Children (Basel, Switzerland)
|May 25, 2024
概括
孕妇在怀孕期间摄取维生素B12对胎儿大脑发育至关重要. 然而,目前的研究尚未确定其对儿童神经发育结果的影响,需要进一步研究.
科学领域:
- 营养神经科学 营养神经科学
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 适当的母体维生素B12对于胎儿大脑发育和长期神经发育结果至关重要.
- 了解母体维生素B12对儿童发育的确切影响对于公共卫生至关重要.
- 现有的流行病学数据需要全面地图,以确定知识差距.
研究的目的:
- 进行人类流行病学研究对母亲维生素B12和儿童神经发育的范围审查.
- 绘制有关产前维生素B12与儿童大脑,认知,语言和运动发育之间的关联的当前证据.
- 确定研究缺口,并提出该领域未来的研究方向.
主要方法:
- 在PubMed和OVID MEDLINE数据库中进行了系统的搜索.
- 搜索术语包括"维生素B12"",产前"或"产妇",以及"神经发育"或"认知发育"或"大脑".
- 如果这些研究评估了母亲的维生素B12状况,摄入量,补充或缺乏以及儿童神经发育结果 (年龄<18岁),则将这些研究纳入. 动物研究被排除在外. 在148个已识别的出版物中,有19个符合标准.
主要成果:
- 范围审查确定了19项相关的人类流行病学研究.
- 证据表明,怀孕期间母亲的维生素B12状况与儿童的神经发育结果之间的联系是不确定的.
- 维生素B12摄入量,补充剂或缺乏与各种神经发育领域之间的具体关联仍然不清楚.
结论:
- 目前的证据不足以确定母体维生素B12与儿童神经发育结果之间的明确关系.
- 进一步进行高质量的纵向研究是必不可少的,以澄清母体维生素B12的作用.
- 未来的研究应该关注母亲的维生素B12补充,状态和摄入量,以更好地了解其对大脑发育和神经发育轨迹的影响.
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