青春期的肥胖因素:具有挑战性的方面和预防策略
Marina Nicolaou1, Meropi Toumba2,3, Alexandros Kythreotis1
1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Children (Basel, Switzerland)
|May 25, 2024
概括
环境肥胖原体或内分泌干扰化学物质 (EDC) 通过破坏荷尔蒙平衡,导致儿童肥胖流行. 在关键发育时期减少暴露是预防的关键.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 儿童肥胖是一个由饮食和不活动驱动的全球流行病.
- 新出现的证据表明内分泌干扰化学物质 (EDCs),特别是肥胖原体,在肥胖的发展.
- 肥胖原体是破坏新陈代谢过程和激素平衡的环境化学物质.
研究的目的:
- 审查环境肥胖因子在儿童肥胖中的作用.
- 探索肥胖源,机制,发育影响和表观遗传效应.
- 讨论儿童肥胖的后果,并提出预防策略.
主要方法:
- 关于肥胖因子和儿童肥胖的文献综述.
- 分析肥胖机制,包括基因表达,荷尔蒙干扰和炎症.
- 检查发育暴露窗口和表观遗传影响.
主要成果:
- 肥胖物质会破坏荷尔蒙平衡和代谢过程.
- 在关键发育时期暴露会显著增加肥胖风险.
- 儿童肥胖有严重的长期健康和心理社会后果.
结论:
- 解决遗传,环境和生活方式因素的综合方法对于打击儿童肥胖至关重要.
- 预防策略必须包括减少肥胖原体暴露和促进健康的生活方式.
- 需要进一步研究肥胖原与饮食相互作用,微生物组和长期人类研究.
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