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富罗塞米德和管关闭在非常低出生体重的早产婴儿:一个全面的回顾性研究
Chi-Mei Kuo1, Pin-Chun Su1, Shu-Ting Yang1
1Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung City 80756, Taiwan.
Children (Basel, Switzerland)
|May 25, 2024
概括
罗塞米德不会影响早产婴儿的动脉管道自发关闭. 研究结果表明,罗塞米德使用与延迟导管关闭之间没有相关性,这表明妊娠年龄是一个更重要的因素.
科学领域:
- 新生儿医学 新生儿医学
- 儿童心脏病学 儿童心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 延迟的动脉管关闭在早产婴儿中很常见.
- 前列腺素会影响导管通透度,而罗塞米德的作用尚不清楚.
- 富罗塞米德可能会增加脏前列腺素合成,影响导管关闭.
研究的目的:
- 为了研究furosemide和在出生体重非常低的早产婴儿中自发管道关闭之间的关系.
- 为了评估罗塞米德暴露时间和累积剂量对导管关闭的影响.
- 为了确定furosemide是否延迟了专利性动脉管道的自发关闭.
主要方法:
- 对105名出生时体重非常低的早产婴儿进行了回顾性分析,这些早产婴儿接受了专利性动脉管道治疗.
- 在治疗方案中包括液体限制和furosemide的使用.
- 通过心声回声仪评估导管关闭,评估罗塞米德的暴露和剂量.
主要成果:
- 罗塞米德暴露与自发管道关闭之间没有发现显著的相关性 (p = 0.384).
- 罗塞米德暴露不会延迟经期后的年龄在自发的导管关闭 (p = 0.558).
- 自发管道关闭的时间与罗塞米德处方日数 (p = 0.026) 呈正相关,与妊娠年龄 (p = 0.062) 呈反相关.
结论:
- 处方Furosemide不会影响自发动脉道关闭的概率或持续时间.
- 累积的富罗塞米德剂量对导管关闭的影响很小.
- 观察到的相关性可能源于治疗方案和妊娠年龄,而不是直接的罗塞米德效应.
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