在从三重疗法转换为双重疗法后,研究与艾滋病毒感染者的身体功能和氧化压力相关分子的变化
Jessica Cusato1, Anna Mulasso2, Micol Ferrara3
1Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.
Antioxidants (Basel, Switzerland)
|May 25, 2024
概括
从三重治疗转换为双重治疗,可能会改变抗氧化剂水平,但不会改变身体功能. 这项研究强调了艾滋病毒感染者 (PLWH) 氧化应激生物标志物的潜在变化.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 艾滋病毒/艾滋病研究研究
背景情况:
- 身体活动可以影响氧化应激生物标志物,影响抗逆转录病毒药物代谢和艾滋病毒感染者 (PLWH) 的临床结果.
- 目前的趋势显示,PLWH的抗逆转录病毒治疗 (ART) 从三重转变为双重,对身体功能和氧化应激的数据有限.
- 了解这些变化对于优化护理和管理ART治疗方案的潜在副作用至关重要.
研究的目的:
- 在从三重到双重ART过渡期间,研究PLWH中抗氧化生物标志物和物理功能中的潜在差异.
- 评估ART疗法改变对氧化应激标志物和身体表现的影响.
- 提供关于在体力活动和氧化应激的背景下切换ART的生理影响的见解.
主要方法:
- 在三重ART的基线上评估了25个PLWH,并在切换到双重ART后的6个月后.
- 使用经过验证的评估工具量化物理功能.
- 通过液态染色学测量线粒体和细胞质中抗氧化分子.
主要成果:
- 在三重和双重ART之间的线粒体谷氨水平中观察到统计学上显著的差异,但在物理测试中没有.
- 对身体活跃与不活跃个体的分析表明,在三重 (n-formyl-methionine,triglycerides) 和双重 (glycine,glutamic acid,s-adenosylmethionine) ART下,特定生物标志物的显著差异.
- 这些发现表明,与ART治疗方案的变化和身体活动水平相关的抗氧化剂配置文件的潜在变化.
结论:
- 这项研究为从三重到双重ART过渡的PLWH中抗氧化剂分子和物理功能的潜在差异提供了新的见解.
- 结果表明,虽然身体功能可能保持稳定,但特定的抗氧化生物标志物可能会受到ART疗法修改的影响.
- 需要进一步的研究来阐明这些生化变化的临床影响及其与PLWH体育活动的关系.
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