通过喷雾干燥封装W/O/W Acerola乳液:优化,释放动力学和储存稳定性
Yen Thi Dang1,2, Hieu Tran2, Tuyen Chan Kha2
1Faculty of Food Science and Technology, Ho Chi Minh City University of Industry and Trade, Ho Chi Minh City 700000, Vietnam.
Foods (Basel, Switzerland)
|May 25, 2024
概括
使用响应表面方法 (RSM) 优化了acerola果粉的喷雾干燥. 该研究确定了维生素C,多和黄的最佳温度,粉末在10°C时具有良好的稳定性.
科学领域:
- 食品科学与技术 食品科学与技术
- 营养生物化学 营养生物化学
- 工艺工程是过程工程.
背景情况:
- 阿塞罗拉 (Malpighia emarginata DC.) 是一种的植物. 是一种富含维生素C和化合物的热带水果.
- 这些生物活性化合物具有显著的健康益处.
- 有效的加工对于保持阿塞罗拉的营养价值至关重要.
研究的目的:
- 为了优化喷雾干燥参数用于acerola粉末生产.
- 为了评估粉末中的生物活性化合物的释放动力学和稳定性.
- 确定最佳的输入和输出温度,以最大限度地提高产量和生物活性化合物保留.
主要方法:
- 使用响应表面方法 (RSM) 采用中央复合材料设计.
- 优化喷雾干燥的入口和出口温度.
- 分析总多,黄和维生素C的水分含量,工艺产量和封装效率.
- 在不同的存储条件下评估溶解特性和粉末稳定性.
主要成果:
- 最佳喷雾干燥入口和出口温度分别为157°C和91°C.
- 为关键参数开发了高精度预测模型 (R2 ≥0.88).
- 预测的单层水分含量低于4.01% (BET方程).
- 总多,黄和维生素C的封装产量分别为61.44%,37.42%和27.19%.
- 阿塞罗拉粉在酸性食品模拟中显示出良好的溶解性和在10°C储存时的优越稳定性.
结论:
- 使用RSM的喷雾干燥优化有效地保留了acerola的生物活性化合物.
- 由此产生的阿塞罗拉粉具有有利的溶解和稳定性.
- 建议在10°C进行最佳储存,以便在30天内保持粉末质量.
相关概念视频
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:16Drug Product Stability
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
01:20Modified-Release Drug Delivery Systems: Influencing Factors
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...