在SARS-CoV-2感染后六个月,功能测试和持续的eGFR降低在临床诊断为COVID后综合征的患者中
Madalina Boruga1, Susa Septimiu-Radu2, Prashant Sunil Nandarge3
1Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Biomedicines
|May 25, 2024
概括
在SARS-CoV-2感染6个月后,患有后COVID综合征的患者表现出持续的功能障碍,以较低的估计膜过率 (eGFR) 和较高的肌水平为证. 在最初的COVID-19疾病期间急性损伤预测长期功能障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 目前正在调查SARS-CoV-2感染的长期影响,包括超越急性阶段的系统性影响.
- 后COVID综合征与各种持续性健康问题有关,需要对特定器官系统参与的研究.
- 在SARS-CoV-2感染后,功能需要进一步评估,以了解潜在的长期后果.
研究的目的:
- 在被诊断患有后COVID综合征的患者感染SARS-CoV-2后六个月评估功能测试.
- 假设和调查持续的功能障碍,通过与基线相比改变的功能测试表明.
- 为了确定持续估计的淋巴球过率 (eGFR) 在感染后六个月下降到30mL/min/1.73m2以下的预测因素.
主要方法:
- 在"维克多·贝贝斯"医院进行的回顾性观察性研究,涉及已确认感染SARS-CoV-2和COVID后综合征的成年人.
- 排除标准包括先前存在的慢性病或严重的功能障碍.
- 分析功能测试:血清肌素,血液尿素 (BUN),EGFR,蛋白尿和血,比较后COVID患者 (n=92) 与对照组 (n=114).
主要成果:
- 后COVID组表现出显著更高的血清肌素 (109.7μmol/L与84.5μmol/L,p < 0.001) 和BUN (23.7 mg/dL与15.2 mg/dL,p < 0.001) 的水平.
- 在COVID后组中观察到显著较低的EGFR (65.3毫升/分钟/1.73米2 vs. 91.2毫升/分钟/1.73米2,p < 0.001).
- 在最初的COVID-19疾病期间,急性损伤 (AKI) 的发展是降低eGFR (β = 3.47,p < 0.001) 的强有力的预测因素,以及肌素和白素与肌素比率 (ACR) 的升高.
结论:
- 患有后COVID综合征的患者在SARS-CoV-2感染后六个月表现出显著的功能障碍.
- 这些发现强调了COVID-19对功能持续的影响,强调了持续监测的必要性.
- 影响后COVID综合征的个体对脏健康的干预策略至关重要.
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