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Updated: Jun 25, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

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基于特拉斯图祖马布的ADC的安全概况:分析EudraVigilance中注册的真实世界数据

Claudiu Morgovan1, Carmen Maximiliana Dobrea1, Anca Butuca1

  • 1Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.

Biomedicines
|May 25, 2024
PubMed
概括

特拉斯图祖马布德鲁克斯泰坎 (T-DXd) 和特拉斯图祖马布埃姆坦辛 (T-DM1) 是针对HER2阳性乳腺癌的抗体-药物结合体. T-DM1显示心脏风险更高,而T-DXd则有更多的胃肠道和代谢不良事件.

关键词:
欧德拉 警 监控 监控 监控HER2阳性乳腺癌是什么意思针对HER2的向疗法.不良反应是不良反应.抗体 - 药物联合体描述性分析 描述性分析不成比例性分析分析药物监督和药物监督特拉斯图祖马布可以脱.特拉斯图祖马布 (Trastuzumab) 是一种素.

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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
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