降低IL-1β分泌作为艾滋病毒诊断的个体肺结核复发的潜在预测因素
Marina Nosik1, Konstantin Ryzhov1, Asya V Kudryavtseva2
1I.I. Mechnikov Institute of Vaccines and Sera, 105064 Moscow, Russia
Biomedicines
|May 25, 2024
概括
调查结核病 (TB) 在HIV/TB同时感染的复发,这项研究发现较低的Interleukin-1β (IL-1β) 水平预测二次结核病. 这种细胞因子可能是结核病复发风险的关键生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 对结核病 (TB) 免疫能力的机制,特别是与艾滋病毒同时感染的免疫能力,尚未完全理解.
- 对于结核病复发和共同感染个体的成功治疗结果的预测生物标志物有迫切需要.
- 鉴定艾滋病毒/结核病联合感染中结核病复发的免疫标志物对于患者管理至关重要.
研究的目的:
- 为了确定与结核病复发相关的潜在免疫标志物,在艾滋病毒和结核病同时感染的患者.
- 为了研究特定细胞因子在结核病免疫反应中的作用,在HIV联合感染的背景下.
主要方法:
- 测量了干扰因子- (IFN-γ),瘤坏死因子-α (TNF-α),介质素-10 (IL-10) 和介质素-1β (IL-1β) 的血水平.
- 酶相关免疫吸收试验 (ELISA) 套件用于细胞因子量化.
- 研究包括211名参与者:艾滋病毒/结核病联合感染,艾滋病毒单一感染,结核病单一感染和健康的捐赠者.
主要成果:
- 与艾滋病毒或结核病单一感染组相比,同时感染艾滋病毒/结核病的患者显示IFN-γ,TNF-α和IL-10水平降低.
- 在艾滋病毒/结核病组内,新诊断的结核病和复发性结核病之间没有观察到IFN-γ,TNF-α或IL-10的显著差异.
- 与新诊断的艾滋病毒/结核病患者相比,在复发性结核病的艾滋病毒/结核病组中检测到IL-1β水平显著下降,约为4倍.
结论:
- 在患有二次性结核病的HIV/TB患者中,显著降低的IL-1β水平表明它有可能成为TB复发的生物标志物.
- 作为TB复发的预测标志物,IL-1β值得进一步研究在HIV/TB同时感染的个体中.
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