瘤中雄激素受体阳性的频率:一项评估超过18,000种瘤的研究
Florian Viehweger1, Jennifer Hoop1, Lisa-Marie Tinger1
1Institute of Pathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Biomedicines
|May 25, 2024
概括
受体 (AR) 存在于许多癌症和正常组织中. 免疫组织化学分析显示了116种瘤类型的AR阳性,在乳腺和清细胞脏细胞癌中具有预后作用.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 受体 (AR) 是一种关键的转录因子,与各种癌症有关.
- 抗逆转录是一种经过验证的治疗点,特别是在前列腺癌中.
- 了解不同瘤类型的AR表达对于向治疗的开发至关重要.
研究的目的:
- 综合分析人类瘤和正常组织的广泛范围内的雄激素受体 (AR) 表达.
- 评估AR免疫组织化学的潜在诊断和预后效用.
- 确定可能受益于AR向治疗的瘤类型.
主要方法:
- 免疫组织化学 (IHC) 在一个大型组织微阵列 (TMA) 上进行,包括18234个瘤样本 (141种) 和608个正常组织样本 (76种).
- 量化了AR阳性和染色强度.
- 统计分析将AR表达与组织病理特征,临床阶段和患者存活率相关联.
主要成果:
- 在141种瘤类型中的116种瘤中检测到AR阳性.
- 高AR表达在丸性带瘤,前列腺,乳腺,脏和膀瘤中突出.
- 较低的AR染色与尿道癌和侵袭性乳腺癌的晚期和糟糕的生存率相关,以及清细胞和乳头细胞癌 (RCC) 的高等级/阶段.
结论:
- AR免疫组织化学在区分瘤类型方面具有有限的作用,但在乳腺和透明细胞RCC中显示出预后意义.
- AR表达模式突出了特定的瘤实体,需要对AR向治疗策略进行调查.
- 对AR信号通路的进一步研究可能会为各种恶性瘤发现新的治疗途径.
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